Effect of Irrigation-Activation Techniques on Healing in Large Periapical Lesions

R

Recep Tayyip Erdogan University

Status

Completed

Conditions

Effect of Irrigation Activation on Periapical Healing

Treatments

Procedure: Passive ultrasonic activation
Procedure: Laser activation
Procedure: Manual dynamic activation

Study type

Interventional

Funder types

Other

Identifiers

NCT06204887
2023/35

Details and patient eligibility

About

The aim of this study was to highlight the healing rates of large periapical lesions after different irrigation activation treatments as manual dynamic activation (MDA), passive ultrasonic irrigation (PUI), shock wave-enhanced emission photoacoustic streaming (SWEEPS) using CBCT scans based on volumetric change analysis during 1-year follow-up.

Full description

The aim of this study was to highlight the healing rates of large periapical lesions after different irrigation activation treatments as manual dynamic activation (MDA), passive ultrasonic irrigation (PUI), shock wave-enhanced emission photoacoustic streaming (SWEEPS) using CBCT scans based on volumetric change analysis during 1-year follow-up. A total of 56 systemically healthy male/female patients with mandibular single-rooted teeth with a periapical index score (PAI) of 3 or higher were included in the study. Pretreatment lesion volumes were determined by CBCT. Patients were randomly divided into 3 study groups (PUI, SWEEPS, MDA) and control group (n=14). For the follow-up routine, 2D radiographs were taken at months 3, 6, and 9, as well as clinical examinations. At the end of 12 months, 3D evaluation of lesion volumes was performed using ITK SNAP. Pretreatment and follow-up values were statistically analyzed with the Wilcoxon test.

Enrollment

56 patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Patients having single root mandibular teeth
  • Patients the diagnosis of chronic apical periodontitis,
  • Periapical index score of 3 and above,
  • Patients having good oral hygiene

Exclusion criteria

  • Patients with systemic diseases (diabetes, hypertension, chronic liver disease, coagulation disorders),
  • Patients with bone metabolism disease and/or
  • Patients using drugs that affect bone metabolism (such as steroids, bisphosphonates)
  • Patients with a history of radiotherapy
  • Pregnant patients
  • Teeth with mobility of 2 or more, periodontal pocket depth of 5 mm or more, generalized chronic periodontitis, internal and external resorption, and/or vertical and horizontal root fractures

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Single Blind

56 participants in 4 patient groups

Manual dynamic activation
Experimental group
Treatment:
Procedure: Manual dynamic activation
Passive ultrasonic activation
Experimental group
Treatment:
Procedure: Passive ultrasonic activation
Laser activation
Experimental group
Treatment:
Procedure: Laser activation
Non-activated Control
No Intervention group

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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