Effect of Irrigation-Activation Techniques on Healing in Large Periapical Lesions

Recep Tayyip Erdogan University

Status: Completed

Conditions: Effect of Irrigation Activation on Periapical Healing

Treatments: Procedure: Passive ultrasonic activation; Procedure: Laser activation; Procedure: Manual dynamic activation

Study type: Interventional

Funder types: Other

Identifiers

NCT06204887

2023/35

Details and patient eligibility

About

The aim of this study was to highlight the healing rates of large periapical lesions after different irrigation activation treatments as manual dynamic activation (MDA), passive ultrasonic irrigation (PUI), shock wave-enhanced emission photoacoustic streaming (SWEEPS) using CBCT scans based on volumetric change analysis during 1-year follow-up.

Full description

The aim of this study was to highlight the healing rates of large periapical lesions after different irrigation activation treatments as manual dynamic activation (MDA), passive ultrasonic irrigation (PUI), shock wave-enhanced emission photoacoustic streaming (SWEEPS) using CBCT scans based on volumetric change analysis during 1-year follow-up.

A total of 56 systemically healthy male/female patients with mandibular single-rooted teeth with a periapical index score (PAI) of 3 or higher were included in the study. Pretreatment lesion volumes were determined by CBCT. Patients were randomly divided into 3 study groups (PUI, SWEEPS, MDA) and control group (n=14). For the follow-up routine, 2D radiographs were taken at months 3, 6, and 9, as well as clinical examinations. At the end of 12 months, 3D evaluation of lesion volumes was performed using ITK SNAP. Pretreatment and follow-up values were statistically analyzed with the Wilcoxon test.

Enrollment: 56 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients having single root mandibular teeth
• Patients the diagnosis of chronic apical periodontitis,
• Periapical index score of 3 and above,
• Patients having good oral hygiene

Exclusion criteria

• Patients with systemic diseases (diabetes, hypertension, chronic liver disease, coagulation disorders),
• Patients with bone metabolism disease and/or
• Patients using drugs that affect bone metabolism (such as steroids, bisphosphonates)
• Patients with a history of radiotherapy
• Pregnant patients
• Teeth with mobility of 2 or more, periodontal pocket depth of 5 mm or more, generalized chronic periodontitis, internal and external resorption, and/or vertical and horizontal root fractures

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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56 participants in 4 patient groups

Manual dynamic activation

Experimental group

Treatment:

Procedure: Manual dynamic activation

Passive ultrasonic activation

Experimental group

Treatment:

Procedure: Passive ultrasonic activation

Laser activation

Experimental group

Treatment:

Procedure: Laser activation

Non-activated Control

No Intervention group