Effect of Ketalar to Prevent Postoperative Chronic Pain After Mastectomy

Civil Hospices of Lyon

Status and phase: Unknown; Phase 4

Conditions: Breast Cancer; Pain

Treatments: Drug: ketalar

Study type: Interventional

Funder types: Other

Identifiers

NCT00129597

2004.349

Details and patient eligibility

About

Prevalence of chronic pain after mastectomy is beyond 50% 3 months after surgery. This pain is related to a sensitization of the central nervous system through N-methyl-D-asparate (NMDA) receptors. Ketalar might prevent the occurrence of chronic pain by anti-NMDA properties after mastectomy.

Sex: Female

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Mastectomy in patients 18 to 80 years old

Exclusion criteria

• American Society of Anesthesiology (ASA) class >= 3
• Renal, heart or hepatic failure
• Allergy to ketalar
• Psychiatric disease
• Chronic antalgic treatment

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind