Effect of Ketamine Added to Intravenous Patient-controlled Analgesia on Postoperative Pain, Nausea and Vomiting in Patients Undergoing Lumbar Spinal Surgery

Yonsei University

Status and phase: Completed; Phase 4

Conditions: Postoperative Nausea and Vomiting

Treatments: Drug: Ketamine; Drug: Saline

Study type: Interventional

Funder types: Other

Identifiers

NCT01394406

4-2009-0670

Details and patient eligibility

About

Ketamine added to intravenous patient-controlled analgesia may be effective on prevention of postoperative nausea and vomiting by reducing opioid requirement after surgery.

Enrollment: 50 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Non-smoking female patients undergoing elective lumbar spinal surgery
• Age 20-65
• American Society of Anesthesiologists physical status classification I or II

Exclusion criteria

• Antiemetic within 24 hrs, Taking Steroids, Opioids within 1 week
• Psychiatric disease, Active drug or alcohol abuse
• GI motility disorder, severe renal/ hepatic disease
• insulin-dependent DM
• admission to ICU after surgery

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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50 participants in 2 patient groups, including a placebo group

Ketamine group

Experimental group

Treatment:

Drug: Ketamine

Saline group

Placebo Comparator group

Treatment:

Drug: Saline