Effect of Ketamine/Midazolam Premedication Versus Pre-extubation Ketofol on Recovery Profile in Pediatrics Undergoing Adenotonsillectomy.
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About
An optimum recovery profile after AT includes a rapid, smooth awakening without emergence agitation (EA), stable vital signs and oxygenation, reduced postoperative nausea and vomiting (PONV), controlled postoperative pain, and patient or parents' satisfaction. Ketamine is a low-cost drug with a wide therapeutic window. Ketamine is a competitive N-methyl-D-aspartate receptor antagonist with good analgesic properties and periprocedural amnesia.
The ketamine/midazolam combination was administered in different ways with controversial results about their effect on the EA and recovery profile.
Ketofol, a mixture of ketamine and propofol, has been used in different favorable recovery profiles regarding postoperative EA and PONV.
This study aims to evaluate the effect of premedication with an intramuscular ketamine/ midazolam combination versus pre-extubation ketofol on the EA and the recovery profile.
Enrollment
Sex
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Volunteers
Inclusion criteria
- ASA physical status I or II
- Children scheduled for AT under general anesthesia (GA).
Exclusion criteria
- Congenital cardiovascular anomalies
- Behavioral changes
- Delayed physical development
- Children receiving sedatives or anticonvulsants therapy
Trial design
Primary purpose
Allocation
Interventional model
Masking
140 participants in 2 patient groups
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Central trial contact
Abeer Ahmed
Data sourced from clinicaltrials.gov
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