Effect of Ketamine on Analgesia Post-Cardiac Surgery

Jewish General Hospital

Status and phase: Completed; Phase 4

Conditions: Pain, Postoperative

Treatments: Drug: Normal Saline Flush, 0.9% Injectable Solution_#1; Drug: Ketamine Hydrochloride

Study type: Interventional

Funder types: Other

Identifiers

NCT02925858

16-289

Details and patient eligibility

About

Randomized, controlled, double-blind pilot study evaluating the effect of an intraoperative infusion of intravenous Ketamine on the quantity of opioid consumed postoperatively in coronary artery bypass surgery patients receiving a median sternotomy.

Full description

This is a randomized, controlled, double-blind pilot study to determine the effectiveness of intraoperative Ketamine administration on pain after coronary artery bypass surgery. Patients will be randomized to receive ketamine or saline prior to incision, with a continuous infusion throughout surgery. Opioid dose administered in the first 48 hours will then be documented as the primary outcome

Enrollment: 80 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients 18 years of age or older coming for coronary artery bypass surgery with a left ventricular ejection fraction over 50% and able to consent prior to surgery

Exclusion criteria

• Minimally invasive cardiac surgery
• Preoperative opioid use
• Preoperative hepatic or renal dysfunction

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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80 participants in 2 patient groups, including a placebo group

Intervention

Experimental group

Description:

Intraoperative infusion of ketamine

Treatment:

Drug: Ketamine Hydrochloride

Control

Placebo Comparator group

Description:

Control group receiving a saline infusion

Treatment:

Drug: Normal Saline Flush, 0.9% Injectable Solution_#1