Effect of Ketogenic Diet on Muscle Hypertrophy

University of Padova

Status: Enrolling

Conditions: Healthy Nutrition

Treatments: Other: resistance training; Other: western diet; Other: ketogenic diet

Study type: Interventional

Funder types: Other

Identifiers

NCT05897567

KETO-EX

Details and patient eligibility

About

The purpose of this study is to investigate the effects of 4 weeks of carbohydrate deprivation (through a ketogenic diet) on hypertrophy signalling after a single bout of exercise in healthy trained male subjects, and the impact on body composition, muscle strength, and blood parameters.

Enrollment: 24 estimated patients

Sex: Male

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• at least 2 years of resistance-training experience
• Body mass index: more than 18 kg/m2 and less than 30 kg/m2

Exclusion criteria

• metabolic diseases or noncommunicable diseases (cardiovascular, liver, respiratory, cancer, etc)
• experience with the ketogenic diet (last six months)
• acute inflammatory status
• treatment with steroids in the past 3 months

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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24 participants in 2 patient groups

ketogenic diet

Experimental group

Description:

Participants will perform a single exercise bout after 4 weeks of resistance training combined with a ketogenic diet (KD group).

Treatment:

Other: resistance training

Other: ketogenic diet

western diet

Active Comparator group

Description:

Participants will perform a single exercise bout after 4 weeks of resistance training combined with a western diet (WD group).

Treatment:

Other: resistance training

Other: western diet