Effect of Ketorolac and Remote Ischemic Preconditioning on Renal Ischemia-reperfusion Injury in Patients Undergoing Partial Nephrectomy

Yonsei University

Status: Completed

Conditions: Renal Cell Carcinoma

Treatments: Drug: Ketorolac tromethamine and remote ischemic preconditioning

Study type: Interventional

Funder types: Other

Identifiers

NCT01836406

4-2012-0485

Details and patient eligibility

About

Partial nephrectomy is a widely accepted alternative to radical nephrectomy in patients with clinically localized, unilateral renal cell carcinoma and a normal contralateral kidney. Interruption of renal blood flow via pedicle clamping is often necessary during partial nephrectomy, especially for complex tumors with deep parenchymal invasion. Ischemia-reperfusion injury is a complex process involving several mechanisms including renal vasoconstriction, extensive tubular damage and glomerular injury. The investigators will examine the postoperative renal function of patients who received intraoperative ketorolac and remote ischemic preconditioning during partial nephrectomy.

Enrollment: 16 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA l and ll
• age 20-65
• patients undergoing partial nephrectomy

Exclusion criteria

• preoperative liver or renal dysfunction,
• coagulopathy,
• chronic alcoholism,
• hypersensitivity of NSAID,
• history of warfarin,
• history of gastric ulcer

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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16 participants in 2 patient groups, including a placebo group

Keromin Group

Experimental group

Treatment:

Drug: Ketorolac tromethamine and remote ischemic preconditioning

Placebo Group

Placebo Comparator group