Effect of Krill Oil on Cognitive Function in Adults

Pusan National University Yangsan Hospital

Status: Completed

Conditions: Subjective Memory Impairment

Treatments: Dietary Supplement: Placebo group; Dietary Supplement: Krill oil group

Study type: Interventional

Funder types: Other

Identifiers

NCT04347421

02-2020-006

Details and patient eligibility

About

The investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects of Krill oil on cognitive function in adults with subjective memory impairment for 12 weeks.

Full description

Previous animal studies have indicated that Krill oil may have the ability to improve cognitive function. Therefore, the investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects of Krill oil on cognitive function in adults with subjective memory impairment for 12 weeks; the safety of the compound are also evaluate. The Investigators examine chemical and metabolic parameters, and cognitive function at baseline, as well as after 6 and 12 weeks of intervention. One hundred adults were administered either 500 mg of Krill oil or a placebo each day for 12 weeks.

Enrollment: 100 patients

Sex: All

Ages: 55 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Global Deterioration Scale (GDS) 2 or 3

Exclusion criteria

• Abnormal liver or renal function (i.e., serum aminotransferase activity > 3 times of upper limit of reference range and serum creatinine concentrations > 1.2 mg/dL)
• Diabetes (diagnosed clinically or fasting glucose level > 126 mg/dL)
• History of viral hepatitis or cancer
• Uncontrolled hypertension
• History of serious cardiac disease such as angina or myocardial infarction
• History of gastrectomy
• History of medication for psychiatric disease
• Administration of oriental medicine including herbs within the past 4 weeks

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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100 participants in 2 patient groups, including a placebo group

Krill oil group

Experimental group

Description:

This group takes Krill oil for 12 weeks

Treatment:

Dietary Supplement: Krill oil group

Placebo group

Placebo Comparator group

Description:

This group takes Placebo for 12 weeks

Treatment:

Dietary Supplement: Placebo group