Effect of L-Citrulline on Vascular Function

Texas Tech University

Status: Completed

Conditions: Aging; Blood Flow; Citrulline

Treatments: Other: Placebo; Dietary Supplement: L-citrulline

Study type: Interventional

Funder types: Other

Identifiers

NCT03127917

15BGIA22710012

Details and patient eligibility

About

The objective of this project is to determine the importance of peripheral vascular function on gait performance in older adults.

Full description

This project employed a placebo controlled, double-blind, crossover trial. Participants were randomized to oral L-citrulline (6 g/day) or placebo (maltodextrin) for 14 days, and switched to the other treatment for another 14 days after washout. Peripheral vascular function was assessed under conditions of rest, leg exercise, and cognitive engagement. Gait performance was assessed using clinical walking tests.

Enrollment: 25 patients

Sex: All

Ages: 60 to 79 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• older adults
• women and men
• aged 60-79 yrs
• must be able to swallow capsules
• fully mobile without assistive walking devices

Exclusion criteria

• have physician diagnosed cardiovascular, pulmonary, or metabolic disease
• are current smokers
• currently taking medications affecting cardiovascular function
• have high blood pressure (>159/99 mmHG)
• have high fasting blood glucose (>110 mg/dL)
• are considered obese (body mass index ≥ 30 kg/m2)
• have orthopaedic limitations that limit walking ability
• have pacemaker or other metal objects in their body

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

---

25 participants in 2 patient groups

CitrullinePlacebo

Experimental group

Description:

Subjects allocated to the CitrullinePlacebo study arm received L-citrulline first, followed by placebo.

Treatment:

Dietary Supplement: L-citrulline

Other: Placebo

PlaceboCitrulline

Experimental group

Description:

Subjects allocated to the PlaceboCitrulline study arm received placebo first, followed by L-citrulline.

Treatment:

Dietary Supplement: L-citrulline

Other: Placebo