Effect of L-PRF and A-PRF in Ridge Preservation

Universitaire Ziekenhuizen KU Leuven

Status: Completed

Conditions: Atrophic Maxilla; Ridge Preservation

Treatments: Other: L-PRF; Other: A-PRF

Study type: Interventional

Funder types: Other

Identifiers

NCT03268512

B322201525149

Details and patient eligibility

About

A split-mouth design study will be performed regarding the use of platelet concentrates on ridge preservation: L-PRF vs A-PRF vs control. Patient needing multiple teeth extractions in the upper jaw (single-rooted teeth) will be recruited. The use of each platelet concentrate or control will be randomized by means of a computer program. The results will be analysed clinical and radiographically (CBCT). When the subject will choose for implant rehabilitation, a biopsy will be taken in the site of the preserved sockets. The region will be localized with a customized stent, fabricated with the position of the extracted teeth. VAS scales will be provided to evaluate the post-operative discomfort.

Enrollment: 20 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 3 single-rooted teeth needed to be extracted in the upper jaw
• patient in good general health as documented by self-assessment
• patients must be committed to the study and must be willing to sing the informed consent.

Exclusion criteria

• any systemic medical condition that could interfere with the surgical procedure or planned treatment.
• current pregnancy or breast feeding
• radiotherapy or chemotherapy in head and neck area
• intravenous and oral bisphosphonate
• patients smoking >20 cig/day
• unwillingness to return for the follow-up examination

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

20 participants in 3 patient groups

L-PRF

Experimental group

Description:

One socket will be filled with L-PRF membranes and covered with at least 2 L-PRF membranes. A modified horizontal mattress will be place as suture to keep the L-PRF in place.

Treatment:

Other: L-PRF

A-PRF

Experimental group

Description:

One socket will be filled with A-PRF membranes and covered with at least 2 A-PRF membranes. A modified horizontal mattress will be place as suture to keep the A-PRF in place.

Treatment:

Other: A-PRF

Control

No Intervention group

Description:

The socket will be filled with a natural blood clot. A modified horizontal mattress will be place as suture.