Effect of Lactobacillus Rhamnosus on Serum Uremic Toxins in Hemodialysis

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nooshin dalili

Status

Completed

Conditions

Hemodialysis Complication

Treatments

Dietary Supplement: Lactobacillus rhamnosus
Drug: Placebo - Cap

Study type

Interventional

Funder types

Other

Identifiers

NCT03527680
IRCT20154182017N21

Details and patient eligibility

About

Uremic toxins such as p-cresol and phenol are suggested to be associated with higher mortality in hemodialysis patients. The aim of this study was to investigate the effects of probiotics on serum p-cresol level in hemodialysis patients.

Full description

Overall, 42 hemodialysis patients (10 women and 32 men) were divided randomly into the Lactobacillus rhamnosus group (21 patients) and the placebo group (21 patients).

Enrollment

42 patients

Sex

All

Ages

20+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:• Age more than 20 years

  • Acceptable performance of alimentary system
  • Ability to drink at least 200 ml of water per day
  • No history of being allergic to fungi and yeast
  • Absence of acute medical illness
  • life expectancy more than 3 months
  • Accept and sign the consent

Exclusion Criteria:

  • Patient's unwillingness to participate in the study
  • History of smoking, peritoneal dialysis (PD) or previous kidney transplantation
  • Lactation or pregnancy
  • Drug history including antibiotics, prebiotics, probiotics, herbal drugs, psychedelic drugs, flavors.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

42 participants in 2 patient groups, including a placebo group

Lactobacillus rhamnosus
Experimental group
Description:
received daily one capsule containing 1.6*107 CFU of Lactobacillus Rhamnosus
Treatment:
Dietary Supplement: Lactobacillus rhamnosus
Placebo
Placebo Comparator group
Description:
received one placebo capsule per day Infant formula after meal for 28 days
Treatment:
Drug: Placebo - Cap

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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