Effect of Laparoscopic Ovarian Drilling on Outcomes of in Vitro Fertilisation in Clomiphene-resistant Women With Polycystic Ovary Syndrome

Ain Shams University

Status: Unknown

Conditions: PCOS

Treatments: Procedure: IVF/ICSI

Study type: Interventional

Funder types: Other

Identifiers

NCT03527979

rkamal

Details and patient eligibility

About

the polycystic ovarian syndrome is associated with an ovulation and infertility. recently the laparoscopic ovarian drilling has been used as surgical treatment for ovulation in women with polycystic ovarian syndrome, although its mechanism and outcomes are still unclear. this study is undertaken to evaluate the in vitro fertilisation outcomes in clomiphene-resistant women with PCOS who were treated with LOD.

Enrollment: 88 patients

Sex: Female

Ages: 25 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age between 25 and 35
• patients with established PCOS
• history at least one year infertility
• no response to clomiphene citrate for at least three cycles

Exclusion criteria

• history of previous IVF/ICSI
• chronic disease such as thyroid disorder and DM
• infertility due to sever male factor
• sever endometriosis
• infertility due to uterine factor such as multiple fibroid
• body mass index > 30

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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88 participants in 2 patient groups

PCOS women with history of LOD before IVF/ICSI

Active Comparator group

Treatment:

Procedure: IVF/ICSI

PCOS women without history of drilling

Active Comparator group

Treatment:

Procedure: IVF/ICSI