Effect of Laser and Potassium Nitrate Application on the Sensitivity Control in Bleached Teeth

Universidade Federal do Para

Status and phase: Completed; Phase 1

Conditions: Dentin Sensitivity

Treatments: Drug: Low Level Laser Therapy; Drug: 5% potassium nitrate / 2% sodium fluoride gel; Drug: In-office dental bleaching

Study type: Interventional

Funder types: Other

Identifiers

NCT03434782

UFPara-002

Details and patient eligibility

About

To investigate the effects of desensitizing agents on the dental bleaching process, testing the hypothesis that they may control dental sensitivity.

Full description

The objective of this double blind, randomized and controlled clinical study, was to evaluate the efficacy of potassium nitrate / sodium fluoride (KNO3 / KF) gel associated with LLLT (Low Level Light Therapy) on teeth that were exposed to 35% hydrogen peroxide during 3 weeks of bleaching treatment. Methods: 50 volunteers were evaluated through the split-mouth model, where the hemiarcates were randomized and later allocated in one of the experimental groups: G1 (negative control)- group with no desensitizing treatment, only bleached; G2 (positive control)- group treated with LLLT + placebo gel; G3- group treated with placebo laser application + 5% KNO3 / 2% KF gel; and G4- group treated with LLLT + 5% KNO3 / 2% KF gel.

Enrollment: 50 patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Absence of active carious lesions;
• Never undergone bleaching therapy;
• Good oral hygiene;
• Do not present hypersensitivity;
• Do not smoke;
• Not being pregnant;
• Presence of at least 28 teeth in oral cavity.

Exclusion criteria

• Presence of periodontal disease;
• Presence of cracks or fractures;
• Presence of restorations and prostheses;
• Presence of gastroesophageal dysfunction;
• Patients with severe internal dental dimming;
• Presence of periodontal disease;
• Presence of dentin exposure in anterior and/or posterior teeth.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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50 participants in 4 patient groups

G1- Negative Control

Experimental group

Description:

Group with no desensitizing treatment. Prior to bleaching therapy, a water-soluble placebo gel, with non-active agent will be applied to dental vestibular surfaces. After bleaching therapy, the LASER tip will be positioned in two points (apical and cervical), without light emission (placebo).

Treatment:

Drug: In-office dental bleaching

G2- LASER (Positive Control)

Experimental group

Description:

Group treated with placebo gel before bleaching and with LLLT after in-office bleaching.

Treatment:

Drug: In-office dental bleaching

Drug: Low Level Laser Therapy

G3- KNO3 (Positive Control)

Experimental group

Description:

Group treated with desensitizing gel before bleaching and after in-office bleaching, the LASER tip will be positioned in two points (apical and cervical), without light emission (placebo).

Treatment:

Drug: In-office dental bleaching

Drug: 5% potassium nitrate / 2% sodium fluoride gel

G4- KNO3 + LASER

Experimental group

Description:

Group treated with desensitizing gel before bleaching and with LLLT after in-office bleaching.

Treatment:

Drug: In-office dental bleaching

Drug: 5% potassium nitrate / 2% sodium fluoride gel

Drug: Low Level Laser Therapy