Effect of Laser Treatment for Diabetic Retinopathy on the Optic Disc Topography

University of Sao Paulo General Hospital

Status: Completed

Conditions: Diabetic Retinopathy

Treatments: Procedure: Panretinal photocoagulation

Study type: Observational

Funder types: Other

Identifiers

NCT03476967

USaoPauloGH 12423

Details and patient eligibility

About

This study analyzed diabetic patients without evidence of glaucoma who underwent panretinal photocoagulation to determine the effect on optic disc topographic parameters in non-glaucomatous patients with proliferative diabetic retinopathy (PDR).

Full description

Glaucoma and proliferative diabetic retinopathy (PDR) are two very prevalent diseases that often coexist. Previous literature suggest that panretinal photocoagulation may somehow lead to optic disk cupping. Therefore, evaluation of the optic disc cupping and of possible glaucomatous damage in patients with diabetic retinopathy can be difficult, especially after PRP treatment. The purpose of this study is to determine the long-term effect of PRP on optic disc topographic parameters in non-glaucomatous patients with PDR using Heidelberg retina tomograph (HRT) parameters and stereo photography. The Investigators found that PRP does not cause morphological optic disk changes in diabetic PDR patients after one year of follow-up.

Enrollment: 30 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosis of PDR (due to type 1 or 2 diabetes mellitus)
• intraocular pressure < 18 mmHg
• nonglaucomatous optic disc characteristics at fundus examination
• vertical cup-to-disc (C/D) ratio <0.7
• absence of media opacities

Exclusion criteria

• previous diagnosis of glaucoma
• family history of glaucoma
• neuroophthalmic disease
• uveitis
• retinal artery or vein occlusion
• optic disc neovascularization
• diabetic macular edema (DME)
• corneal opacity
• previous laser photocoagulation treatment

Trial design

30 participants in 1 patient group

Pretreatment x Posttreatment

Description:

The group was evaluated through non-invasive complementary examinations before laser therapy and at the 1-year follow-up visit to analyze possible optical disc alterations that may occur after retinal panretinal photocoagulation in patients with proliferative diabetic retinopathy.

Treatment:

Procedure: Panretinal photocoagulation