Effect of Left Atrial Appendage Velocity on Left Atrial Structure and Function After Radiofrequency Ablation Combined With Left Atrial Appendage Occlusion

Hebei Medical University

Status: Completed

Conditions: Left Atrial Appendage Velocity; Left Atrial Structure; Left Atrial Function

Treatments: Device: Transesophageal ultrasound

Study type: Observational

Funder types: Other

Identifiers

NCT04693871

XieRuiqinLAAEV

Details and patient eligibility

About

Radiofrequency ablation of atrial fibrillation combined with left atrial appendage closure can not only improve symptoms in patients with non-valvular atrial fibrillation, but also prevent left atrial appendage thrombosis. The safety and effectiveness of left atrial appendage occlusion have been confirmed by randomized controlled trials and actual experience. Among patients with different left atrial appendage emptying speeds, there are limited studies on the structure and function of the left atrial appendage after LAA closure. In this study, patients with persistent nonvalvular atrial fibrillation were selected for radiofrequency ablation combined with LAA closure. The sinus rhythm was restored after the operation. According to the different emptying speed of the left atrial appendage, they were divided into a high-flow rate group and a low-flow rate group. The differences in the structure and function of the left atrium between the two groups were analyzed.

Enrollment: 100 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Patients who received atrial fibrillation radiofrequency ablation combined with left atrial appendage closure.

Exclude Criteria

• Patients with incomplete data.
• Device embolism.
• Residual shunt around the device found by transesophageal echocardiography greater than 5 mm.
• Mitral valve stenosis.
• Artificial valve.
• Atrial septal defect.
• Dilated cardiomyopathy
• Moderate Severe mitral regurgitation

Trial design

100 participants in 2 patient groups

high-flow rate group

Treatment:

Device: Transesophageal ultrasound

low-flow rate group

Treatment:

Device: Transesophageal ultrasound