Effect of Lidocaine and Adrenaline Soaked Gauze Versus Normal Saline Soaked at Skin Graft Donor Site of Thigh

Dow University of Health Sciences

Status: Completed

Conditions: Non-healing Wound

Treatments: Drug: 2% Lidocaine and 1:100,000 Adrenaline; Drug: Normal saline

Study type: Interventional

Funder types: Other

Identifiers

NCT04344483

1506

Details and patient eligibility

About

Investigator is studying the effects of Lidocaine and Adrenaline Soaked Gauze vs Normal Saline Soaked Gauze at Skin Graft Donor Site of Thigh.

Haemostatic effect, epithelization and post operative pain will be assessed on follow up.

Full description

After admission participants will be randomized either to be in Group A or Group B. Closed envelop technique will be used for random assignment of the patients.

Group A will be receiving 2% lidocaine and 1:100,000 adrenaline soaked gauze while group B will be given only normal saline soaked gauze at donor-site for ten minutes.

The primary end point of study is intraoperative bleeding. The secondary end points of study include no. of dressings required in first 24 hours after surgery, donor site epithelization at 14th post-operative day, post-operative pain in first 24 hours after surgery along with systemic analgesia requirement after surgery.

Enrollment: 60 patients

Sex: All

Ages: 15+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• • Patients of both the gender of age > 15 years

  • Multiple donor-sites

Exclusion criteria

Bleeding disorder

• Concomitant injuries
• Donor site other than thigh
• Previously harvested donor-site
• Patients on antiplatelet medications

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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60 participants in 2 patient groups, including a placebo group

Group A ( Lidocaine + Adrenaline)

Active Comparator group

Description:

Group A patients will receive 2% Lidocaine and 1:100,000 adrenaline soaked gauze over skin graft donor site of thigh per operatively for 10 minutes. After 10 minutes this dressing will be removed and sufratul dressing will be applied over donor site.

Treatment:

Drug: 2% Lidocaine and 1:100,000 Adrenaline

Group B ( Normal Saline)

Placebo Comparator group

Description:

Group B patients will receive normal saline soaked gauze over skin graft donor site of thigh intraoperatively for 10 minutes. After 10 minutes this dressing will be removed and sufratul dressing will be applied over donor site

Treatment:

Drug: Normal saline