Effect of Lidocaine/Dexamethasone on the Success of IANB

Isfahan University of Medical Sciences

Status and phase: Completed; Phase 3; Phase 2

Conditions: Local Anesthesia

Treatments: Drug: Dexamethasone; Drug: 2% lidocaine with 1:80,000 epinephrine; Drug: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT03531970

396731

Details and patient eligibility

About

The purpose of this prospective, randomized, double-blind study was to compare the success rate of IAN block injection carried out with two cartridges of 2% lidocaine with 1:80000 epinephrine each combined with 0.2 ml dexamethasone versus two cartridges of 2% lidocaine with 1:80000 epinephrine each combined with 0.2 ml sterile distilled water for endodontic treatment of mandibular molars with symptomatic irreversible pulpitis.

Full description

Several investigations have been carried out to demonstrate the effect of dexamethasone added to local anesthetics in regional block injections. These investigations shown that the addition of dexamethasone to local anaesthetics may prolong the duration of anesthesia and also results in a faster onset. It is hypothesized that dexamethasone added to lidocaine may affect the success rate of inferior alveolar nerve block

Enrollment: 100 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• vital mandibular molar tooth
• diagnosis of symptomatic irreversible pulpitis

Exclusion criteria

• younger than 18 years old
• history of significant medical conditions
• allergies to local anesthetics or sulfites
• pregnancy
• taking any medications that might influence anesthetic assessment
• active sites of pathosis in area of injection
• inability to give informed consent

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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100 participants in 2 patient groups, including a placebo group

Dexamethasone

Experimental group

Description:

lidocaine \& Dexamethasone

Treatment:

Drug: 2% lidocaine with 1:80,000 epinephrine

Drug: Dexamethasone

Non-dexamethasone

Placebo Comparator group

Description:

lidocaine \& Placebo

Treatment:

Drug: Placebo

Drug: 2% lidocaine with 1:80,000 epinephrine