Effect of Lidocaine Plus Dexmedetomidine Infusion on PONV

Xu Siqi

Status: Completed

Conditions: Dexmedetomidine; Lidocaine; Nausea and Vomiting, Postoperative

Treatments: Drug: saline IV; Drug: lidocaine and dexmedetomidine IV

Study type: Interventional

Funder types: Other

Identifiers

NCT03788018

AnqingMH

Details and patient eligibility

About

BACKGROUND: Few researches have manifested that intravenous (IV) lidocaine or dexmedetomidine decreased the incidence of postoperative nausea and vomiting (PONV). The investigators investigated whether IV lidocaine plus dexmedetomidine infusion could better reduce the incidence of PONV after laparoscopic hysterectomy.

METHODS: One hundred and twenty women with elective laparoscopic hysterectomy were randomly divided into two groups: patients in the lidocaine combined with dexmedetomidine group (LD group, n=60) received lidocaine (1.5 mg/kg loading, 1.5 mg/kg/h infusion) and dexmedetomidine (0.5 μg/kg loading, 0.4 μg/kg/h infusion) respectively. Patients in the control group (CON group, n=60) received the equal volume of saline. Primary outcome was the incidence of the first 48 h nausea, vomiting and PONV after surgery. The secondary outcomes included perioperative propofol and remifentanil consumption, postoperative fentanyl requirement, Ramsay sedation score, and bradycardia during post-anaesthesia care unit (PACU) stay.

Enrollment: 60 patients

Sex: Female

Ages: 40 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists (ASA) physical statusⅠand Ⅱ
• Aged 40-55 years
• Scheduled for elective laparoscopic hysterectomy

Exclusion criteria

• History of allergy to local anesthetics
• Severe respiratory disease
• Renal or hepatic insufficiency
• History of preoperative opioids medication and psychiatric
• preoperative bradycardia
• preoperative atrioventricular block
• Subjects who experienced severe hypotension (mean arterial pressure [MAP] <60 mmHg) or bradycardia (heart rate [HR] <40 bpm), urticaria, or arrhythmia during lidocaine and dexmedetomidine infusion period

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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60 participants in 2 patient groups

Effect of IV lidocaine and dexmedetomidine on PONV

Experimental group

Treatment:

Drug: lidocaine and dexmedetomidine IV

Drug: saline IV

Effect of IV saline on PONV

Experimental group

Treatment:

Drug: lidocaine and dexmedetomidine IV

Drug: saline IV