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The goal of this clinical trial is to to evaluate the efficacy of lidocaine sprayed at the laryngeal inlet combined with the endotracheal tube cuff compare with intravenous lidocaine on the hemodynamic response to laryngoscopy and intubation in patients undergoing elective neurological procedures during general anesthesia with total intravenous technique.
The main question it aims to answer is:
Participants will be recruited and randomized to receive either lidocaine spray (Group SL) or intravenous lidocaine (group IL) to blunt hemodynamic response to laryngoscopy and intubation.
Full description
Anesthetic protocol
Preoperative
Intraoperative Pre-induction phase
Intervention: prepared before induction anesthesia.
Induction phase
At 5 minutes after cisatracurium injection, direct laryngoscopy will be performed, and spray 10%lidocaine directly to the epiglottis for 4 puffs for SL group.
All the adverse events (cough, pulmonary aspiration, desaturation, hypotension, hypertension, tachycardia, bradycardia, and arrythmia) will be noted as yes or no.
Enrollment
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Primary purpose
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Interventional model
Masking
50 participants in 2 patient groups
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Central trial contact
Nattawadee Phokaw, MD
Data sourced from clinicaltrials.gov
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