Effect of Lidocaine Sprayed on Hemodynamics During Endotracheal Intubation

Seoul National University

Status: Unknown

Conditions: Neurosurgical Patients

Treatments: Drug: group LV; Drug: group C; Drug: group V; Drug: group L

Study type: Interventional

Funder types: Other

Identifiers

NCT01737437

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Details and patient eligibility

About

A previous study demonstrated topical lidocaine spray on the larynx and the trachea is effective in reducing hemodynamic response to laryngoscopy and endotracheal intubation. In clinical practice, blind oropharyngeal application of lidocaine without aiding direct laryngoscopy can not assured that sprayed lidocaine effectively reaches the larynx and trachea. Therefore, direct laryngoscopy should be necessary to reach topical lidocaine to correct sites. Unfortunately, direct laryngoscopy itself can affect hemodynamics during spraying lidocaine. In this study, we will investigate an effect of lidocaine sprayed on direct laryngoscopy and the tracheal mucosa on hemodynamic change throughout intubation.

Enrollment: 80 estimated patients

Sex: All

Ages: 20 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• aged 20-60 years,
• ASA groups I or II

Exclusion criteria

• ASA III or IV,
• hypertension,
• anticipated difficult airway, and
• severe coronary and cerebrovascular diseases

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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80 participants in 4 patient groups, including a placebo group

group L

Experimental group

Description:

10% Lidocaine was applied to the laryngoscope blade and 0.9% normal saline was applied to the trachea.

Treatment:

Drug: group L

group C

Placebo Comparator group

Description:

0.9% normal saline was applied to trachea and laryngoscope blade in Group C.

Treatment:

Drug: group C

group V

Experimental group

Description:

0.9% normal saline was applied to the laryngoscope blade and 10% Lidocaine was applied on trachea.

Treatment:

Drug: group V

group LV

Experimental group

Description:

10% Lidocaine was applied on laryngoscope blade and trachea.

Treatment:

Drug: group LV