Effect of Loading of Midazolam or Dexmedetomidine on Hemodynamics

Konkuk University Medical Center

Status and phase: Withdrawn; Phase 4

Conditions: Knee Injuries

Treatments: Drug: dexmedetomidine group; Drug: midazolam group

Study type: Interventional

Funder types: Other

Identifiers

NCT02634021

KUH1160088

Details and patient eligibility

About

Loading dose of dexmedetomidine is related hemodynamic instability such as bradycardia and hypertension.

Full description

The investigators hypothesized substitution of loading of dexmedetomidine for midazolam could reduce hemodynamic instability during spinal anesthesia for knee arthroscopy.

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients who were planned to undergo knee arthroscopy under spinal anesthesia

Exclusion criteria

• age < 20 years
• underlying heart, liver or kidney disease
• hypersensitivity to midazolam or dexmedetomidine

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Single Blind

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0 participants in 2 patient groups

dexmedetomidine group

Active Comparator group

Description:

dexmedetomidine 1 mcg/kg intravenous loading followed by dexmedetomidine continuous infusion at the rate of 0.5 mcg/kg/hr

Treatment:

Drug: dexmedetomidine group

midazolam group

Experimental group

Description:

midazolam 0.1 mg/kg intravenous loading followed by dexmedetomidine continuous infusion at the rate of 0.5 mcg/kg/hr

Treatment:

Drug: midazolam group