Effect of Local Injury on Implantation

Yazd Research & Clinical Center for Infertility

Status and phase: Completed; Phase 2

Conditions: Implantation Rate

Treatments: Procedure: local injury

Study type: Interventional

Funder types: Other

Identifiers

NCT00846183

local injury111

Details and patient eligibility

About

Local injury on two sights of endometrium are performed in 60 patients in their first IVF cycle and implantation rate are compared with fresh cycles without local injury.

Full description

Low implantation rate is still a major concern in ART cycles. It has been reported that local injury to endometrium may improve endometrial receptivity and implantation rate. A total of 120 patients in first IVF cycles, who are stimulated with long protocol, are randomly divided into two groups. In one group, on the day of oocyte retrieval, local injury to endometrium with a Novak curet to anterior and posterior wall of endometrium are performed and in the other group no interventions are done. After fresh embryo transfers, implantation and clinical pregnancy rates are compared between two groups.

Enrollment: 156 patients

Sex: Female

Ages: Under 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age < 35
• First IVF cycle
• Long protocol should be used for stimulation

Exclusion criteria

• Day 3 FSH > 10

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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156 participants in 2 patient groups

local ingury

Active Comparator group

Description:

In one group, on the day of oocyte retrieval, local injury to endometrium with a Novak curet to anterior and posterior wall of endometrium are performed.

Treatment:

Procedure: local injury

control

No Intervention group

Description:

in 60 patients routine IVF are performed