Effect of Location of Tetanic Stimuli on Photoplethysmogram Under General Anesthesia

University of California San Francisco (UCSF)

Status: Completed

Conditions: Stress Reaction

Treatments: Device: Tetanic Stimulus

Study type: Interventional

Funder types: Other

Identifiers

NCT05899686

PT1502

Details and patient eligibility

About

The effect of the location of tetanic stimulus on photoplethysmography signals will be studied in patients under general anesthesia.

Full description

A 5 second 100 Hz 70 mA tetanic stimulus will be applied to three different locations (Ulnar nerve, Facial nerve, Posterior Tibial nerve) in a random order in patients who are under general anesthesia. Tetanic stimuli are used routinely during general anesthesia to assess effectiveness of neuromuscular blockade. These tetanic stimuli are noxious stimuli that elicit a stress response which can be quantified using photoplethysmography. This study investigates if the magnitude of the tetanus induced stress response is dependent on the location of the tetanic stimulus as measured by photoplethysmography.

Enrollment: 12 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Surgical patients
• Undergoing general anesthesia
• Able to consent in english
• 18 years of age or older

Exclusion criteria

• Under 18 years of age
• unable to consent in english
• receiving regional anesthesia

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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12 participants in 1 patient group

Tetanic Stimulus

Experimental group

Description:

all participants receive the same intervention, which is three tetanic stimuli applied to three different anatomical locations. The three anatomical locations are identical in all subjects.

Treatment:

Device: Tetanic Stimulus