Effect of Long-term Transcranial Direct Current Stimulation (tDCS) on Appetite Control Related Brain Regions

Chungbuk National University

Status: Completed

Conditions: Obesity

Treatments: Device: sham tDCS; Device: real tDCS

Study type: Interventional

Funder types: Other

Identifiers

NCT02362633

2014-07-018

Details and patient eligibility

About

The purpose of this study is to investigate the long-term effect of Transcranial Direct Current Stimulation (tDCS) on appetite control related brain regions.

Full description

Transcranial direct current stimulation (tDCS) is emerging tool for brain modulation in a variety of clinical conditions. In addition, recent neuroimaging studies suggest that modifying the activity of brain circuits involved in eating behavior could provide therapeutic benefits in obesity.

The investigators aim to assess whether long-term modulation of the dorsolateral prefrontal cortex (DLFPC) using tDCS, modifies behavioral response and brain activity while watching visually presented food cues and taste cues in obese subjects.

Subjects will be randomly divided into sham and real tDCS arms. Subjects will receive sham or real tDCS ten times. Subjects will be investigated before and after sham or real tDCS interventions. Subjects will perform functional MRI experiments with visual and taste food cues. Questionnaire with behavior measures, body compositions, blood tests will be performed.

Enrollment: 27 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI > 26 kg/m2

Exclusion criteria

• History of brain trauma, epilepsy, or other neurological problems

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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27 participants in 2 patient groups

Real tDCS

Experimental group

Description:

Subjects will receive real tDCS treatment for ten times for two weeks (five times per week).

Treatment:

Device: real tDCS

Sham tDCS

Sham Comparator group

Description:

Subjects will receive sham tDCS treatment for ten times for two weeks (five times per week).

Treatment:

Device: sham tDCS