Effect of Low-carbohydrate/High-fat Diet on Glucose Tolerance and Lipid Profile in Lean, Healthy Women (LCHF)

Atlantis Medical University College

Status: Completed

Conditions: Weight; Insulin Sensitivity

Treatments: Other: LCHF diet and a bout of exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT02005224

AMUC-NIH-LCHF-P1-2012

Details and patient eligibility

About

Intervention studying the effect of a low-carbohydrate/high-fat (LCHF) diet as well as on bout of exercise in combination with either a normal diet or a LCHF diet, in relation to glucose metabolism, insulin sensitivity, lipid profile and body composition.

Enrollment: 17 patients

Sex: Female

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Females
• Normal weight
• BMI between 18.5 and 25
• Moderately trained

Exclusion criteria

• Smokers/tobacco users
• pregnancy
• familial cardio-vascular-disease
• diabetes or reduced glucose tolerance
• under- or overweight (BMI under 18.5 or over 25)
• top athletes

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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17 participants in 1 patient group

LCHF diet and a bout of exercise

Other group

Description:

LCHF diet for 3 weeks, where E% 70 fat, E% 20-25 proteins and 20g or less carbohydrates. Oral glucose tolerance test on the morning of day 21 followed by a bout of exercise in the afternoon (indoor bicycle, 60min at 75% HFpeak). The following morning (day 22) a new oral glucose tolerance test. Oral glucose tolerance test results from pre-tests used to determine the effect of LCHF and a bout of exercise on insulin sensitivity.

Treatment:

Other: LCHF diet and a bout of exercise