Effect of Low Dose Radiotherapy on Brain Amyloidosis in the Treatment of Alzheimer's Disease

Valentina Garibotto

Status

Active, not recruiting

Conditions

Alzheimer Disease

Treatments

Radiation: Low dose radiotherapy

Study type

Interventional

Funder types

Other

Identifiers

NCT03352258

2017-01715

Details and patient eligibility

About

Alzheimer's Disease (AD) is the most frequent neurodegenerative disease associated with dementia, with a constantly increasing prevalence associated with an aging population. Amyloid deposition is considered the first molecular event occurring in AD: as already showed in an animal model, a low-dose radiotherapy (RT) course is capable of reducing AD-associated amyloid-β plaques and improve cognitive function. This pilot study wishes to investigate in 10 patients with a diagnosis of prodromal or early probable AD and with evidence of amyloid pathology the effectiveness of a short course low dose RT radiotherapy to reduce amyloid deposits in the human brain using molecular imaging (18F-Florbetapir) to show the effectiveness of the treatment on the specific target.

Enrollment

20 patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Ability to understand the clinical trial and give an informed consent
Clinical diagnosis of prodromal AD, or mild or moderate AD
Ability to undergo neurocognitive assessment at baseline visit, alone or accompanied by a caregiver
Amyloid PET scan positivity
Ability to follow the 5-days RT regiment, alone or accompanied by a caregiver

Exclusion criteria

Inclusion in another disease modifying clinical trial
Previous therapeutic brain irradiation
Evidence of vascular cognitive impairment on Magnetic Resonance Imaging (MRI) (Fazekas score >1 and Wahlund score >=10/30)
Oncologic disease (excluding skin cancer) active or in remission from less than 5 years
Evidence of substance abuse (alcohol and/or other drugs) with a dependence during the previous 12 months (DSM-IV criteria)
Presence of subdural hygroma's, subdural hematomas or hydrocephalus
Significant psychiatric comorbidity as assessed during the clinical evaluation by the neurologist/geriatrician in charge
Active or recent (within 3 months) cerebral infection/haemorrhage
Immunocompromised status
Prior history of seizure
Dermatological skin disease of the scalp
Women who are pregnant or breast feeding or who intend to become pregnant during the course of the study;
Lack of safe contraception, defined as: female participants of childbearing potential, not using and not willing to continue using a medically reliable method of contraception for the entire study duration, such as oral, injectable, or implantable contraceptives, or intrauterine contraceptive devices, or who are not using any other method considered sufficiently reliable by the investigator in individual cases;