Effect of Low-Level Laser on Crevicular Interleukin-1β Concentration in Patients with Periodontal Disease: a Relation to Periodontal Inflammaging

Misr University for Science and Technology

Status: Completed

Conditions: Old Age; Periodontal Diseases

Treatments: Radiation: diode laser as adjunctive to conventional scaling and debridement; Procedure: conventional scaling and debridement

Study type: Interventional

Funder types: Other

Identifiers

NCT06677385

2022/0082

Details and patient eligibility

About

This study is done to compare between young age and old age patients with periodontitis (inflammaging) and the effect of diode laser as adjunctive to scaling and debridement

Enrollment: 28 patients

Sex: All

Ages: 20+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Male or Female

2. Aged below 40 or above 60.

3. Provide informed consent and willingness to cooperate with study protocol.

4. Periodontitis stage II patients:

   • CAL from 3-4 mm.
   • Radiographic bone loss (15% to 33%).
   • No tooth loss due to periodontitis.
   • Maximum probing depth ≤ 5 mm, mostly horizontal bone loss

Exclusion criteria

1. Patients with heavy smoking habits
2. History of antibiotics in the previous three months.
3. Pregnant or lactating female.
4. Treatment with any systemic drug.
5. History of systemic disease.
6. Patients who received periodontal treatment in the last 6 months

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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28 participants in 4 patient groups

Conventional scaling and debridement in young aged patients

Experimental group

Description:

scaling and debridement

Treatment:

Procedure: conventional scaling and debridement

Conventional scaling and debridement of old aged patients

Experimental group

Treatment:

Procedure: conventional scaling and debridement

diode laser as adjunctive to conventional scaling and debridement for old age patients

Experimental group

Treatment:

Radiation: diode laser as adjunctive to conventional scaling and debridement

diode laser as adjunctive to conventional scaling and debridement for young age patients

Experimental group

Treatment:

Radiation: diode laser as adjunctive to conventional scaling and debridement