Effect of Low-Level Laser Therapy on Salivary Toll Like Receptor- 4 Concentration of Periodontitis Patients: a Relation to Periodontal Inflammaging

Rawda Saleh Saad Alashmawy

Status: Completed

Conditions: Periodontal Disease

Treatments: Procedure: conventional scaling and debridement; Radiation: Diode laser as adjunctive to conventional scaling and debridement

Study type: Interventional

Funder types: Other

Identifiers

NCT06677736

2022\0083

Details and patient eligibility

About

Effect of Low-Level Laser Therapy on Salivary Toll Like Receptor- 4 Concentration of Periodontitis Patients: A Relation to Periodontal Inflammaging

Full description

Effect of Low-Level Laser Therapy on Salivary Toll Like Receptor- 4 Concentration of Periodontitis Patients: A Relation to Periodontal Inflammaging

Enrollment: 40 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Male or Female

2. Aged below 40 or above 60.

3. Have at least 16 natural teeth excluding wisdom.

4. Provide informed consent and willingness to cooperate with study protocol.

5. Periodontitis stage II patients (23):

   • CAL from 3-4 mm.
   • Radiographic bone loss (15% to 33%).
   • No tooth loss due to periodontitis.
   • Maximum probing depth ≤ 5 mm, mostly horizontal bone loss

Exclusion criteria

• 1- Patients with any smoking habits 2- History of antibiotics in the previous three months. 3- Pregnant or lactating female. 4- Treatment with any systemic drug. 5- History of systemic disease. 6- Patients who received periodontal treatment in the last 6 months

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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40 participants in 4 patient groups

conventional scaling and debridement young age patient

Experimental group

Description:

conventional scaling and debridement young age patient

Treatment:

Procedure: conventional scaling and debridement

conventional scaling and debridement old age patient

Experimental group

Description:

conventional scaling and debridement old age patient

Treatment:

Procedure: conventional scaling and debridement

diode laser as adjunctive to scaling and debridement young age patient

Experimental group

Description:

diode laser as adjunctive to scaling and debridement young age patient

Treatment:

Radiation: Diode laser as adjunctive to conventional scaling and debridement

diode laser as adjunctive to scaling and debridement old age patient

Experimental group

Description:

diode laser as adjunctive to scaling and debridement old age patient

Treatment:

Radiation: Diode laser as adjunctive to conventional scaling and debridement