Effect of Low Tidal Volume on Blood Loss During Laparoscopic Hepatectomy

Army Medical University

Status: Unknown

Conditions: Blood Loss

Treatments: Other: Tidal volume

Study type: Interventional

Funder types: Other

Identifiers

NCT03399123

MZK001

Details and patient eligibility

About

To explore the effect of low tidal volume on blood loss and gas exchange during laparoscopic hepatectomy

Full description

Background & Aims:Liver cancer is an disease that threatening human health .Laparoscopic hepatectomy is more and more widely used.It is very important to reduce the bleeding during laparoscopic hepatectomy.The investigators found that low tidal volume can effectively reduce intraoperative bleeding.The aim of this study was to explore the effect of low tidal volume on blood loss and gas exchange during laparoscopic hepatectomy

Enrollment: 104 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Aged from 18 to 70 years old;
2. American association of anesthesiologists(ASA) score I to III;
3. Ability to adhere to the study schedule;
4. Ability to provide informed consent and complete all study assessments;
5. Patients undergoing selective surgery of laparoscopic hepatectomy.

Exclusion criteria

1. The New York Heart Association classification(NYHA) III to IV;
2. Chronic obstructive pulmonary disease,respiratory failure, patients after thoracic surgery.
3. BMI>32Kg/m2;
4. Abnormal in blood coagulation function;
5. Patients with mental disease;
6. Patients with neuromuscular disease;
7. Concurrent enrollment in another Randomized controlled trial(RCT);
8. Absence of written informed consent.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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104 participants in 2 patient groups

Low tidal volume group

Experimental group

Description:

Use a low tidal volume(6'8ml/kg) ventilation mode during liver segmentation。

Treatment:

Other: Tidal volume

Standard tidal volume group

Active Comparator group

Description:

Use a standard tidal volume(10'12ml/kg) ventilation mode during operation.

Treatment:

Other: Tidal volume