Effect of Magnesium Sulphate Added to Mepivacaine Hydrochloride on Inferior Alveolar Nerve Block Success in Patients With Symptomatic Irreversible Pulpitis in Mandibular Molars: A Randomized Clinical Trial.

Cairo University (CU)

Status: Unknown

Conditions: Success of Inferior Alveolar Nerve Block

Treatments: Drug: Magnesium sulfate; Drug: Mepivacaine-Levonordefrin Hydrochloride

Study type: Interventional

Funder types: Other

Identifiers

NCT04561921

ENDO 3-7-1(18/9/20)

Details and patient eligibility

About

the study is conducted to assess the effect of adding magnesium sulphate to mepivacaine HCl compared to mepivacaine HCl alone on the success of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis in mandibular molars

Enrollment: 56 estimated patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Age between 18-55 years old.

2. Systemically healthy patient (ASA I or II).

3. Mandibular molar teeth with:

   • Preoperative sharp pain.
   • No widening in the periodontal ligament (PDL).
   • Vital response of pulp tissue to cold pulp tester (ethyl chloride spray)1.
   • Fully formed roots.

4. Positive patient's acceptance for participation in the study.

Exclusion criteria

1. Patients who had used any type of analgesic medication during the preceding 12 hours before the treatment.
2. Pregnant or nursing females.
3. Patients having significant systemic disorder (ASA III or IV).
4. Drug abusers and subjects who were on antidepressant medication.
5. Re-treatment cases.
6. Patients with a contraindication for the use of magnesium sulphate or those known to be allergic to any of the study medications.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

---

56 participants in 2 patient groups

megnesium sulphate

Experimental group

Description:

Injection of 1.8 mL of an anaesthetic solution containing 1% magnesium sulphate , and 1.8% mepivacaine HCL with .06mg Levonordefrin HCl during inferior alveolar nerve block.

Treatment:

Drug: Magnesium sulfate

mepivacaine HCl

Active Comparator group

Description:

Injection of 1.8 mL of a local anaesthetic solution containing 1.8% mepivacaine HCL with .06mg Levonordefrin HCL during inferior alveolar nerve block

Treatment:

Drug: Mepivacaine-Levonordefrin Hydrochloride