Effect of Magnesium Sulphate on Coagulation

Seoul National University

Status: Completed

Conditions: Myoma

Treatments: Drug: Magnesium Sulfate; Drug: normal saline

Study type: Interventional

Funder types: Other

Identifiers

NCT01032213

TEG/Mg

Details and patient eligibility

About

Arterial and venous thrombotic events are the clinical manifestation of postoperative hypercoagulability. Altered serum magnesium may play a role in the balance of coagulation. In this study, the investigators investigated the effect of magnesium sulphate on the postoperative coagulation change in total intravenous anesthesia (TIVA).

Enrollment: 40 patients

Sex: Female

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA Ⅰ-Ⅱ patients undergoing pelviscopic gynecologic operation under general anesthesia.

Exclusion criteria

• Pregnancy
• Previous known hematologic disorder
• Recent medication interfering with hemostasis
• Severe anemia
• Liver disease
• Cardiovascular or respiratory disease

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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40 participants in 2 patient groups, including a placebo group

group C

Placebo Comparator group

Description:

control group

Treatment:

Drug: normal saline

group M

Experimental group

Description:

magnesium group

Treatment:

Drug: Magnesium Sulfate