Effect of Magnesium Sulphate on Neostigmine

Gachon University Gil Medical Center

Status: Unknown

Conditions: Neuromuscular Blockade

Treatments: Drug: Magnesium Sulfate, Injectable

Study type: Interventional

Funder types: Other

Identifiers

NCT03020706

B-1610/367-002

Details and patient eligibility

About

The purpose of this study is to evaluate the effect of magnesium sulphate on neostigmine-induced reversal of neuromuscular block by rocuronium

Full description

Comparison of reversa time by neostigmine in magnesium group and control group

Enrollment: 166 estimated patients

Sex: All

Ages: 20 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• ASA status 1 or 2
• patients undergoing surgery for more than 60 min under general anesthesia

Exclusion criteria

• electrolyte abnormalities
• medication on aminoglycoside, antiepileptic drug, magnesium
• underweight or obesity (BMI <18.5 or >30)
• renal insufficiency (Cr>1.4 mg/dl)
• AV block
• neuromuscular disease (ex: Myathenia gravis)

Trial design

166 participants in 2 patient groups

Magnesium

Experimental group

Description:

magnesium sulfate, injectable intravenous administration (50mg/kg diluted in 100ml normal saline) during general anesthesia

Treatment:

Drug: Magnesium Sulfate, Injectable

Control

No Intervention group

Description:

No intervention