Effect of Magnesium Supplement in Early Pregnancy After ICSI

Ain Shams University

Status and phase: Unknown; Phase 3

Conditions: ICSI

Treatments: Drug: Magnesium Oxide; Drug: Placebo Oral Tablet

Study type: Interventional

Funder types: Other

Identifiers

NCT03398031

ashams university

Details and patient eligibility

About

Daily supplement of magnesium after biochemical diagnosis of pregnancy in females pregnant after ICSI and through out 1st trimester

Full description

a fall of magnesium levels at 2-3 weeks of gestation. This drop of magnesium concentration is larger following IVF as compared to spontaneous pregnancies.

so magnesium supplement start after biochemical diagnosis of pregnancy and throughout the 1st trimester

Enrollment: 180 estimated patients

Sex: Female

Ages: 25 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age 25_38 years

• BMI 25_30

  • females pregnant after ICSI after biochemical diagnosis of pregnancy

Exclusion criteria

• females with poor ovarian reserve and poor responders

  • abnormality in uterine cavity detected by hysteroscopic evaluation pre ICSI and not treated
  • hydrosalpinx

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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180 participants in 2 patient groups, including a placebo group

Magnesium supplement

Active Comparator group

Description:

90 female pregnant after ICSI after biochemical diagnosis of pregnancy will receive 500 mg magnesium supplement

Treatment:

Drug: Magnesium Oxide

placebo

Placebo Comparator group

Description:

90 female pregnant after ICSI after biochemical diagnosis of pregnancy will receive placebo oral tablet

Treatment:

Drug: Placebo Oral Tablet