Effect of Magnesium Supplementation for Children With Drug Resistant Idiopathic Epilepsy

Ain Shams University

Status: Completed

Conditions: Drug Resistant Epilepsy

Treatments: Dietary Supplement: Magnesium; Drug: Placebo - Concentrate

Study type: Interventional

Funder types: Other

Identifiers

NCT02982824

FMASU M.S 20/2016

Details and patient eligibility

About

Effect of oral magnesium sulfate (Mg) supplementation will be studied. Children with drug resistant idiopathic epilepsy following up in Pediatric Neurology Clinic, Ain Shams University, will be randomized to either Mg add-on treatment group or anti-epileptic drugs AEDs alone. Serum magnesium, seizure control and Intelligent quotation (IQ) will be done at base line and after 6 months of treatment.

Full description

The Aim of this work was to study the effect of Magnesium as add on therapy on clinical seizure control in drug resistant idiopathic epilepsy and IQ.

Enrollment: 60 patients

Sex: All

Ages: 6 to 16 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children with drug resistant idiopathic epilepsy

Exclusion criteria

• Structural, Metabolic, Infectious and Unknown etiology epilepsy
• Any neurological disease other than epilepsy
• Any nutritional disorder
• Any other systemic diseases (including Renal disease, Cardiac arrhythmia)
• Drug intake other than antiepileptic drugs (AED)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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60 participants in 3 patient groups, including a placebo group

Magnesium add-on

Experimental group

Description:

20 children with drug resistant epilepsy will receive oral magnesium sulfate 6 ml per day which equivalent to 400 mg elemental magnesium (Yuen \& Sander, 2012) for 6 months and their regular antiepileptic drugs.

Treatment:

Dietary Supplement: Magnesium

Antiepileptic drugs only

Placebo Comparator group

Description:

20 children with drug resistant epilepsy will receive their regular antiepileptic drugs and placebo for 6 months.

Treatment:

Drug: Placebo - Concentrate

Healthy controls

No Intervention group

Description:

To asses serum magnesium level for comparison with the intervention group.