Effect of Mango on Gut Microbiota and Metabolic Health

Laval University

Status

Unknown

Conditions

Gut Microbiota

Metabolic Syndrome

Treatments

Dietary Supplement: Mango consumption

Study type

Interventional

Funder types

Other

Identifiers

NCT03825276

MANGO 2018-147

Details and patient eligibility

About

Mango is rich in bioactive compounds such as dietary polyphenols and carotenoids, which may explain its beneficial effect on health. Polyphenols accumulate in the gut where they can positively modulate the microbiota. As gut microbiota may have a strong influence on cardiometabolic health, we hypothesize that mango consumption improves metabolic profile in overweight or obese individuals through beneficial changes in gut microbiota. The study of metagenomics, transcriptomics and metabolomics will be used to validate this hypothesis.

Enrollment

35 patients

Sex

All

Ages

18 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy men and premenopausal women
At least one of the following : BMI between 25 and 40 kg/m2 or Waist circumference ≥ 80 cm for women and ≥ 94 cm for men
At least one of the following : TG ≥ 1.35 mmol/L or fasting insulinemia ≥ 42 pmol/L
Caucasian origin

Exclusion criteria

Nicotine use
Metabolic disorders or use of medication that may affect parameters measured in the study
Use of dietary supplements or natural health product that may affect parameters measured in the study
Use of antibiotics in the last 3 months
Surgery in the last 3 months or planned during the study timeline
Alcohol consumption >2 drinks/day
Weight change >5% in the last 3 months
Mango aversion, allergy or intolerance
Dietary restrictions (vegetarian, gluten avoidance...)
Berries consumption >1 serving/day
Pregnancy, breastfeeding or pregnancy planned within 3-6 months