Effect of MCT Emulsification on Ketogenesis in Human Adults

Université de Sherbrooke

Status: Completed

Conditions: Healthy

Treatments: Dietary Supplement: MCT oil 20g; Dietary Supplement: Control; Dietary Supplement: MCT homogenate 30g; Dietary Supplement: MCT oil 30g; Dietary Supplement: MCT homogenate 20g; Dietary Supplement: MCT homogenate 10g; Dietary Supplement: MCT oil 10g

Study type: Interventional

Funder types: Other

Identifiers

NCT02409927

2014-391

Details and patient eligibility

About

Lower brain glucose uptake is present before the onset of cognitive deterioration and may increase the risk of cognitive decline in Alzheimer's disease. Ketones are the brain's main alternative energy substrates. Medium-chain triglycerides (MCT) are rapidly beta-oxidized and are ketogenic. Large doses of MCT oil are linked to gastro-intestinal side effects due to incomplete absorption so the investigators examined whether homogenisation into a skim milk matrix (MCT-H) would both improve ketogenesis and reduce side-effects compared to MCT taken without homogenisation into a matrix (bulk MCT [MCT-B]).

Hypotheses: (i) MCT-H will be better absorbed compared to MCT-B, so MCT-H will result in higher ketonemia and lower side effects in healthy adults. (ii) The effects of MCT-B and MCT-H on ketogenesis will be dose-dependent.

Enrollment: 10 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• aged 18 years or more

Exclusion criteria

• smoker
• pregnancy or breastfeeding
• diabetes or insulin resistance
• uncontrolled thyroid disease, hepatic or renal disease
• uncontrolled high blood pressure
• medical treatment influencing lipid or glucide metabolism
• ongoing or past severe drug or alcohol abuse
• dementia or psychiatric difficulties or depression
• chronic immune condition or inflammation

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

Healthy participant

Other group

Description:

Each participant undergo 7 metabolic day, separate by at least 3 days, where they received a different dietary supplement on each day: control (no supplement), MCT oil 10g, MCT oil 20g, MCT oil 30g (provided from pure MCT oil), MCT homogenate 10g, MCT homogenate 20g, MCT homogenate 30g (provided by a 10% MCT homogenate emulsion)

Treatment:

Dietary Supplement: MCT homogenate 20g

Dietary Supplement: MCT homogenate 30g

Dietary Supplement: MCT oil 30g

Dietary Supplement: MCT homogenate 10g

Dietary Supplement: MCT oil 10g

Dietary Supplement: MCT oil 20g

Dietary Supplement: Control