Effect of Meal Number, Frequency, and Form on Satiety and Metabolism After Weight Loss Surgery

St. Luke's-Roosevelt Hospital Center

Status: Completed

Conditions: Obesity; Gastric Bypass Surgery

Treatments: Other: Liquid Meal; Other: Solid Meal

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT01938469

09-117

Details and patient eligibility

About

Analyze the effect of meal pattern (meal number, frequency, and form) on satiety, gut peptides, insulin, and glucose levels in individuals before and 12-15 months after gastric bypass surgery (GBP).

Full description

The main goal is to study the effect of meal number, size and texture on metabolism and incretin levels after GBP. Patients will be studied before GBP (T0) and 12-15 months after GBP (T1). At T0 and T1, patients will come for 2 study days for 8 hours: On one study day, a single meal will be served, on the second study day, three small isocaloric meals, with the order of the conditions randomly assigned. The total amount of calories and the overall nutrient composition will be equivalent between conditions. The meals will be either all solid or all liquid. Patients enrolled in the study will be randomly assigned to solid or liquid test meals.

Gastric emptying will be measured by the acetaminophen test.

Enrollment: 33 patients

Sex: All

Ages: 21 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Severely obese patients undergoing gastric bypass surgery (GBP)

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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33 participants in 2 patient groups

Solid Meal

Other group

Description:

Participants in this group will be administered only solid meals on both study visits completed before surgery (T0) and 12-15 months after (T1).

Treatment:

Other: Solid Meal

Liquid Meal

Other group

Description:

Participants in this group will be administered only liquid meals on both study visits completed before surgery (T0) and 12-15 months after (T1).

Treatment:

Other: Liquid Meal