Effect of Meal on Portal and Esophagus Variceal Pressure (VIPE)

Hvidovre University Hospital

Status: Terminated

Conditions: Esophageal Varices; Cirrhosis

Treatments: Behavioral: meal (food intake)

Study type: Interventional

Funder types: Other

Identifiers

NCT00485290

H-KF-2007-0050

Details and patient eligibility

About

The reason why esophagus varices suddenly rupture and start to bleed is unclear. Food intake increase the hepatic blood flow and the portal pressure, but it is yet unknown if there is also an increase in variceal pressure. The aim of this study is to evaluate the efficacy of a meal on variceal pressure with a non invasive endoscopic measurement device, and compare it with portal pressure.

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Large Esophageal varices

Exclusion criteria

• Treatment with beta-blocking agents
• Respiratory diseases that contradict endoscopy
• Gastric-retention
• Former gastric resection
• Resent sclerotherapy or former banding

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)