Effect of Meal Texture on Glucose-metabolism and Gut Hormone Response After Bariatric Surgery (Obesity)

Hvidovre University Hospital

Status: Completed

Conditions: Gastric Bypass; Gut Hormones; Glucose Metabolism Disorders; Sleeve Gastrectomy; Obesity

Treatments: Other: Solid meal; Other: Liquid meal

Study type: Interventional

Funder types: Other

Identifiers

NCT04082923

H-19027100

Details and patient eligibility

About

The investigators want to evaluate the difference in glucose metabolism and intestinal hormonal response after a liquid meal versus a solid meal in patients after bariatric surgery.

Enrollment: 36 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age > 18 years
• RYGB or SG operation > 12 months prior to inclusion
• Weight stable (± 3 kg during the last month)
• HbA1c < 48 mmol/mol before surgery, and no history of diabetes
• HbA1c < 48 mmol/mol and fasting plasma glucose < 6.1 mmol/l at inclusion

Exclusion criteria

• Thyrotoxicosis or inadequately treated hypothyreosis
• Hemoglobin < 6.5 mmol/l at inclusion
• Pregnancy or breast feeding
• Medication affecting the planned examinations

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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36 participants in 3 patient groups

Gastric bypass operated patients

Other group

Description:

Two test days in a randomized, patient-blinded, cross-over design

Treatment:

Other: Solid meal

Other: Liquid meal

Gastric sleeve operated patients

Other group

Description:

Two test days in a randomized, patient-blinded, cross-over design

Treatment:

Other: Solid meal

Other: Liquid meal

Control arm

Other group

Description:

Two test days in a randomized, patient-blinded, cross-over design

Treatment:

Other: Solid meal

Other: Liquid meal