Effect of Mechanical Loading With PTH on Cortical Bone

Mass General Brigham

Status and phase: Withdrawn; Phase 4

Conditions: Osteoporosis, Postmenopausal

Treatments: Device: Upper extremity voluntary loading

Study type: Interventional

Funder types: Other

Identifiers

NCT03232476

2017P001094

Details and patient eligibility

About

Clinical trial to investigate effect of voluntary upper extremity loading in combination with anabolic osteoporosis therapy.

Sex: Female

Ages: 45+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• women aged 45+
• postmenopausal
• osteoporotic with high risk of fracture

Exclusion criteria

• no significant previous use of bone health modifying treatments

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

0 participants in 1 patient group

Loaded upper extremity

Other group

Description:

This is a one-arm study. In postmenopausal women prescribed teriparatide for osteoporosis treatment, enrolled subjects will perform voluntary loading exercises on one upper extremity. A data logger device will assist in recording exercises and determining goal force during the exercises. Each subject's non-loaded upper extremity will serve as a control.

Treatment:

Device: Upper extremity voluntary loading