Effect of Medium Chain Triglyceride Intake on Colonization of Preterm Infants With Candida

Joseph Bliss

Status and phase: Completed; Phase 1

Conditions: Candida Infection; Premature Infant

Treatments: Drug: Medium-Chain Triglyceride (MCT) Oil

Study type: Interventional

Funder types: Other

Identifiers

NCT03630770

WIH 13-0088

Details and patient eligibility

About

This study evaluates whether adding a dietary supplement similar to coconut oil (MCT oil) to feedings in premature infants will reduce the amount of yeast (Candida) detectable in their stool. Infants who have Candida in their stool are eligible to participate. Half of the enrolled infants will have additional MCT oil added to their feedings and half will not.

Enrollment: 12 patients

Sex: All

Ages: Under 6 months old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Premature infant admitted to the Neonatal Intensive Care Unit at Women & Infants Hospital
• Receiving full enteral feeds of either preterm or transitional formula or fortified breast milk
• Anticipated to have a minimum stay of two weeks

Exclusion criteria

• Prior exposure to antifungal drugs

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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12 participants in 2 patient groups

Control

No Intervention group

Description:

This group receives no feeding supplement.

MCT Oil

Experimental group

Description:

This group is supplemented with MCT oil

Treatment:

Drug: Medium-Chain Triglyceride (MCT) Oil