Effect of Mental Stress on Platelet Function
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About
The aim of the project is to study the acute and chronic effect of mental stress on platelet adhesion and aggregation in two population composed of normal subjects at different ages
Full description
Psychological stress is an important cardiovascular risk factor. Activation of platelets plays an important role in atherosclerosis development and it could be one of the mechanisms linking psychological stress and cardiovascular diseases.
We plan to include 32 healthy subjects. (16 in every group). One group with subjects at age 20 - 49 and the other group with subjects at age 50 - 70 years.
The aim of the study will be to assess the acute and chronic effect of a standard short mental stress (2-minute Bondet Test) on platelet function and of the level of endothelin-1, catecholamines and cortisol. We plan to evaluate if age may play a role in the effect of psychological stress on platelet function.
Enrollment
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Volunteers
Inclusion criteria
- healthy subjects between 20 - 70 years of age
- written informed consent
- no evidence of diseases
Exclusion criteria
- pregnancy
- oral contraceptives
- smoking
- use of aspirin or NSAIDs within the last week
- use of benzodiazepines within the last week
- Alcohol or drug abuse
- participation in another study within the last month
Trial design
32 participants in 2 patient groups
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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