Effect of Metabolic Dysfunction in Branched-chain Amino Acids on Cardiac Function in Patients With Sepsis

Sichuan University

Status: Not yet enrolling

Conditions: Sepsis

Treatments: Other: Effect of BCAAs metabolic dysfunction on cardiac function in sepsis

Study type: Observational

Funder types: Other

Identifiers

NCT06258252

20240201

Details and patient eligibility

About

The current project was designed to examine the effects of BCAA metabolic dysfunction on cardiac function in septic patients.

Full description

Patients with sepsis and with/without type 2 diabetes will be included. Patients prospectively collected the following indicators in the intensive care unit: 1. myocardial injury-related biomarkers: troponin T and B natriuretic peptide levels; 2. cardiac structure-related indicators: the size of the left and right ventricle, left ventricular ejection fraction, etc.3. septic cardiomyopathy incidence: Troponin T>0.01ng/ml is the standard for the diagnosis of septic cardiomyopathy. Additionally, the investigators will collect the peripheral blood at preoperative, day 1, day 3, and day 5 after surgery. Peripheral blood plasma and PBMCs were separated by differential centrifugation: the concentration of BCAAs in serum and PBMCs; the expression of PBMCs BCAAs metabolic enzymes BCAT 1, BCKDH, and PP 2 Cm by WB; and the levels of AST, ALT, LDH, CK, and CK-MB

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients diagnosed with sepsis with or without type 2 diabetes

Exclusion criteria

• patients with immunodeficient diseases patients who accept glucocorticoid or immunosuppressant patients with an age younger than 18 years patients who cannot provide informed consent

Trial design

50 participants in 2 patient groups

Patients who are diagnosed as sepsis, with type 2 diabetes.

Description:

1. myocardial injury-related biomarkers: troponin T and B natriuretic peptide levels; 2. cardiac structure-related indicators: the size of the left and right ventricle, left ventricular ejection fraction, etc.3. septic cardiomyopathy incidence: Troponin T\>0.01ng/ml is the standard for the diagnosis of septic cardiomyopathy.

Treatment:

Other: Effect of BCAAs metabolic dysfunction on cardiac function in sepsis

Patients who are diagnosed as sepsis, without type 2 diabetes.

Description:

1. myocardial injury-related biomarkers: troponin T and B natriuretic peptide levels; 2. cardiac structure-related indicators: the size of the left and right ventricle, left ventricular ejection fraction, etc.3. septic cardiomyopathy incidence: Troponin T\>0.01ng/ml is the standard for the diagnosis of septic cardiomyopathy.

Treatment:

Other: Effect of BCAAs metabolic dysfunction on cardiac function in sepsis