Effect of Metformin on Gut Microbiota Changes and Glycemic Control of Newly Diagnosed Type 2 Diabetes

Southern University of Science and Technology

Status and phase: Completed; Phase 4

Conditions: Type 2 Diabetes

Treatments: Drug: Metformin Hydrochloride

Study type: Interventional

Funder types: Other

Identifiers

NCT04426422

GUTT2DM

Details and patient eligibility

About

This study was aimed to investigate the effect of metformin on the gut microbiota and glycemic control in newly diagnosed type 2 diabetes patients.

Full description

This study was aimed to investigate the effect of metformin on the gut microbiota and glycemic control in newly diagnosed type 2 diabetes patients. All the recurited patients were treated with metformin 1500-2000mg daily for 3 months. Stool specimens and blood samples were collected at the beginning and 3 months later.

Enrollment: 52 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

newly diagnosis type 2 diabetes ,HbA1c >7 %

Exclusion criteria

history of cardiovascular disease, hypertension, severe renal dysfunction defined as glomerular filtration rate < 45 mL/min/1.73 m2; severe illness or diabetic ketoacidosis within 30 days, inability to tolerate ≥500 mg metformin twice per day and pregnancy.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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52 participants in 1 patient group

metformin group

Experimental group

Description:

all the patients were treated with metformin 1500-2000mg daily for 3 months.

Treatment:

Drug: Metformin Hydrochloride