Effect of Methyldopa on Uterine Artery Diameter in Pregnant Women With Mild Preeclampsia

Isfahan University of Medical Sciences

Status and phase: Completed; Phase 2

Conditions: Pregnant Women With Mild Preeclampsia

Treatments: Drug: Placebo; Drug: Methyldopa

Study type: Interventional

Funder types: Other

Identifiers

NCT01674127

390306

Details and patient eligibility

About

The present study examined the effects of Methyldopa on uterine artery diameter, uterine artery blood flow, umbilical artery and fetal middle-cerebral artery in patients with Preeclampsia, using Doppler ultrasound.

Enrollment: 50 patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

They met the inclusion criteria, If they had over 25 weeks of gestational age, no history of chronic hypertension, no diabetes mellitus, no chronic systemic diseases, no collagen vascular diseases and antiphospholipid syndromes, no use of antihypertensive drugs and BMI higher than 19 and lower than 30 (kg/m2).

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

50 participants in 2 patient groups, including a placebo group

Methyldopa

Experimental group

Description:

In case group, 25 patients, under treatment, using Methyldopa for 7 days, received 500 mgs of Methyldopa in its oral form per day and in control group, participants received placebo for 7 days.

Treatment:

Drug: Methyldopa

placebo

Placebo Comparator group

Treatment:

Drug: Placebo