Effect of Metoclopramide Versus Sumatriptan for Emergency Department Treatment of Migraine Headache

Isfahan University of Medical Sciences

Status and phase: Completed; Phase 2

Conditions: Migraine Disorders

Treatments: Drug: metoclopramide, injection,20mg, one time; Drug: Sumatriptan, injection, 6 mg, one time

Study type: Interventional

Funder types: Other

Identifiers

NCT01791400

ASD-1213-70

Details and patient eligibility

About

The purpose of this study is to determine which drug makes lower migraine headache

Full description

There are different options to manage benign headache in emergency department.The investigators compared Intravenous metoclopramide with Subcutaneous sumatriptan to relieve pain in emergency department.

Enrollment: 124 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 20-60 years old and presented with acute headache similar to previous episodes,
• with or without phonophobia,
• photophobia,
• vomiting or nausea.

Exclusion criteria

• fever or neck stiffness,
• altered mental state,
• pregnancy,
• recent trauma or seizure (within 24 hours),
• focal neurological abnormality on physical examination,
• allergy to metoclopramide,
• hypertension,
• cardiovascular diseases.

Also if the patients had taken a triptan or ergot during the last 24 hours were excluded from the study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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124 participants in 2 patient groups

sumatriptan

Other group

Description:

Patients who underwent 6 mg sumatriptan subcutaneous one time

Treatment:

Drug: Sumatriptan, injection, 6 mg, one time

Metoclopramide

Other group

Description:

Patients who underwent 20 mg Metoclopramide intravenous one time

Treatment:

Drug: metoclopramide, injection,20mg, one time