Effect of Mild Therapeutic Hypothermia on the Doses of Vasopressors and Inotropes in Cardiogenic Shock Complicating Acute Myocardial Infarction

Tanta University

Status: Completed

Conditions: Vasopressors; Inotropes; Mild Therapeutic Hypothermia; Acute Myocardial Infarction; Cardiogenic Shock

Treatments: Drug: Mild therapeutic hypothermia

Study type: Interventional

Funder types: Other

Identifiers

NCT06947616

33716/3/20

Details and patient eligibility

About

The study aimed to assess the effects of mild therapeutic hypothermia (MTH) on vasopressors and inotropes in patients with cardiogenic shock (CS) due to acute myocardial infarction (AMI).

Full description

Cardiogenic shock (CS) is a condition characterized by a severe lack of blood flow to vital organs caused by primary malfunction of the heart, as described by the European Society of Cardiology (ESC) and the American Heart Association (AHA). Acute myocardial infarction (AMI) is a prevalent etiology of CS, constituting a minimum of 30% of the instances. 50% of CS cases manifest upon hospital admission, whereas the remaining 50% occur after hospital admission.

Enrollment: 60 patients

Sex: All

Ages: 50 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age from 50 to 70 years.

• Both sexes.

• Cardiogenic shock post AMI defined by systolic blood pressure <90 mm Hg for >30 minutes or motropes required to maintain a systolic blood pressure >90 mm Hg in the absence of hypovolemia with signs of pulmonary congestion and signs of impaired organ perfusion defined by at least 1 of the following: altered mental status; cold, clammy skin; urine output <30 mL/h; or arterial lactate >2 mmol/L.

  2. Intubated and sedated

Exclusion criteria

1. Self-ventilated
2. Indication for targeted temperature management by current guidelines "out of hospital cardiac arrest with return of spontaneous circulation (ROSC)"

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

60 participants in 2 patient groups

Mild therapeutic hypothermia group

Experimental group

Description:

Patients received mild therapeutic hypothermia (MTH) to 33°C for 24-36 h

Treatment:

Drug: Mild therapeutic hypothermia

Control group

No Intervention group

Description:

Patients did not receive mild therapeutic hypothermia (MTH)