Effect of Minoxidil Solution Iontophoresis on Androgenic Alopecia

Cairo University (CU)

Status: Not yet enrolling

Conditions: Alopecia

Treatments: Other: saline solution iontophoresis; Other: Minoxidil solution iontophoresis

Study type: Interventional

Funder types: Other

Identifiers

NCT07056933

012/005693

Details and patient eligibility

About

The aim of the study is to evaluate the therapeutic efficiency of minoxidil solution iontophoresis on Androgenic Alopecia.

Full description

Hair is an important component of identity and self-image. Hair loss can lead to a variety of psychological difficulties and have a negative impact on quality of life (QoL). Loss of self-confidence lowered self-esteem, and heightened self-consciousness are common responses to hair loss, particularly for women. People with alopecia are more likely to develop depression and anxiety.

Some studies have proposed iontophoresis and ultrasound as energetic drug delivery methods to favor topical therapy of alopecia. Iontophoresis is a non-invasive technique that applies a small electric current (of no more than 0.5 mA/cm2) on the skin's surface to increase and control drug delivery. The technique is widely studied to stimulate the skin penetration and permeation of hydrophilic drugs, which would not be absorbed by the skin when passively applied. The transport of drugs through the skin as a result of the electric current is driven by two different mechanisms, ie, electromigration in the case of charged drugs and electroosmosis in the case of neutral drugs.

Furthermore the need of this study is developed from the lack in quantitative knowledge and information in published studies which investigate effect of minoxidil solution iontophoresis on Androgenic alopecia.

Enrollment: 25 estimated patients

Sex: Male

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Twenty-five adult aged 18-65 with diagnosed androgenic alopecia.
• They diagnosed as Androgenic alopeacia by their physicians and referred for physical therapy management.
• Medically and psychologically stable patients.

Exclusion criteria

• History of hypersensitivity to minoxidil solution or Intophoresis.
• Scalp infection
• Concurrent hair loss treatments.
• Patients who suffer from hypertrophic and/or keloidal scars and a skin condition in the area of Androgenic alopecia that would interfere with study procedures.
• plaque psoriasis, tattoo, birthmark, facial hair.
• Patients with medical red flags as severe psychiatric disorder or cognitive deficits.
• Medically unstable and uncooperative patients.
• Immunocompromised status.
• History of skin cancer.
• Recurrent herpes viral infection.
• Pregnancy or breastfeeding status.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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25 participants in 2 patient groups

Minoxidil-treated scalp

Experimental group

Description:

5% minoxidil through iontophoresis will be applied to one half of the scalp twice daily at home.

Treatment:

Other: Minoxidil solution iontophoresis

Saline-treated scalp

Active Comparator group

Description:

The other half of the scalp will receive a placebo solution, (eg saline) with current application.

Treatment:

Other: saline solution iontophoresis