Effect of Mitomycin C on Urethral Stricture Recurrence After Internal Urethrotomy

Hillel Yaffe Medical Center

Status and phase: Unknown; Phase 2; Phase 1

Conditions: Urethral Stricture

Treatments: Drug: Mitomycin C - local injection; Procedure: Internal urethrotomy

Study type: Interventional

Funder types: Other

Identifiers

NCT00918528

0020-09-HYMC

Details and patient eligibility

About

The aim of this study is to evaluate the efficacy of local injected mitomycin C at the time of internal urethrotomy in order to prevent the recurrence of urethral strictures.

Sex: Male

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male urethral stricture suitable for internal urethrotomy
• Stricture length less than 10 mm

Exclusion criteria

• Stricture length over 10 mm
• Benign prostate enlargement

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

0 participants in 2 patient groups

1. Internal urethrotomy

Active Comparator group

Treatment:

Procedure: Internal urethrotomy

2. Internal urethrotomy + mitomycin C

Experimental group

Treatment:

Procedure: Internal urethrotomy

Drug: Mitomycin C - local injection