Effect of Short-term Descent to Low Altitude in Healthy Residents at Moderate Altitude (>1000 m.a.s.l.).

Tsogyal Latshang

Status: Completed

Conditions: Healthy

Treatments: Diagnostic Test: Descent to low altitude

Study type: Interventional

Funder types: Other

Identifiers

NCT05826808

2023-00636

Details and patient eligibility

About

The purpose of this study is to investigate the effect of short-term descent in healthy residents at moderate altitude (>1000 m.a.s.l.).

Full description

Polysomnographies will be done for each participant for 2 consecutive nights at the sleep laboratory in Chur (CH; 590 m.a.s.l.) as well as for 2 consecutive nights at the participants home elevations (CH; >1000 m.a.s.l.). Between the measurements at those two different altitudes there will be a two-week washout period at >1000 m.a.s.l.. The sequence of altitude exposure will be randomized.

Enrollment: 44 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy (no current medical condition or intake of regular medication, except negligible medical issues or accidents not interfering with the current health status or physical performance.)
• Living above 1000 m.a.s.l. since at least 1 year
• No overnight stay at altitudes <1000 m.a.s.l. in the previous 4 weeks
• 18-70 years old
• Body mass index 18,5-30 kg/m2
• informed consent

Exclusion criteria

• Active diseases or health related conditions that require treatment (sleep disorders (mainly sleep apnea), chronic rhinitis, cardiovascular and lung diseases)
• Use of drugs that affect the respiratory center drive (sedatives, sleep inducing drugs, opioids), stimulants or illegal drugs
• Regular consumption of recreational drugs (alcohol and nicotine included)

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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44 participants in 2 patient groups

A

Experimental group

Description:

Polysomnographies will be done first for 2 nights at the sleep laboratory in Chur (590 m.a.s.l.) and after a two-week washout period for 2 nights at the participants home elevations (\>1000 m.a.s.l.).

Treatment:

Diagnostic Test: Descent to low altitude

B

Experimental group

Description:

Polysomnographies will be done first for 2 nights at the participants home elevations (\>1000 m.a.s.l.). and after a two-week washout period for 2 nights at sleep laboratory in Chur (590 m.a.s.l.).

Treatment:

Diagnostic Test: Descent to low altitude